Moderately clinically significant. You should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin. In March 2012, the U.S. Food and Drug Administration (FDA) updated its guidance for statin users to address reports of memory loss, liver damage, increased blood sugar, development of type 2 diabetes, and muscle injury. Drug interactions are reported among people who take Simvastatin and Flecainide acetate. Major Food Interaction Consumer information for this interaction is not currently available. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. MONDAY, Oct. 17, 2016 (HealthDay News) -- Cholesterol-lowering statins can interact with other drugs prescribed for … Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Food–drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Author links open overlay panel Xue-jia Zhai a Jian-guo Chen b Jin-mei Liu a Fang Shi a Yong-ning Lu a Very Important. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. 40 mg of zocor at night and half an aspirian. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Ezetimibe. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Avoid combinations; the risk of the interaction outweighs the benefit. In some cases, rhabdomyolysis can cause kidney damage and even death. Should I avoid certain foods while taking Niacin-Simvastatin Tablet, Extended Release Multiphase 24 Hr (Tablet, ER Hr)? For non-prescription products, read the label or package ingredients carefully. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. Major Food Interaction Grapefruit juice can significantly increase the blood levels of simvastatin. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Continue to follow the cholesterol-reducing diet recommended by your health care provider. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. You should limit the use of alcohol while being treated with these medications. Grapefruit juice can significantly increase the blood levels of simvastatin. Available for Android and iOS devices. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Simvastatin and niacin combination is used together with a proper diet to lower cholesterol and triglyceride (fat) levels in the blood. Promptly consult your doctor or pharmacist. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. Grapefruit juice can increase simvastatin levels in your body and increase the risk of side effects. You may need to take simvastatin on a long-term basis. Zhai XJ(1), Chen JG, Liu JM, Shi F, Lu YN. Manufacturer advises adjust simvastatin dose. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Notes for Consumers: Simvastatin (Zocor) may be taken with or without food. Common interactions include abdominal symptom among females and palpitations among males. May enhance hepatic side hepatic effects with alcohol. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day A full updated listing of all the interactions is provided in the table below. Clinical pharmacology and therapeutics. In 1991, Merck & Co's simvastatin was approved as an HMG-COA inhibitor to lower the levels of LDL cholesterol. Drug interaction with any of these substances may enhance or decrease the effect of Rosuvastatin. Major Food Interaction. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Food Chem Toxicol. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. WebMD provides information about interactions between Simvastatin Oral and avoid-grapefruit-unless-md-instructs-otherwise. We evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy. We evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy. 2013 Mar;53:168-73. doi: 10.1016/j.fct.2012.11.045. April 1, 2020 Update: The Food and Drug Administration (FDA) announced the recall of all medications containing the ingredient ranitidine, known by the brand name Zantac. Amiodarone. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Rosuvastatin. Consumer information for this interaction is not currently available. Things to remember when you fill your prescription. simvastatin ↔ food. By Amy Norton. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects, including muscle injury. When consumed with food, lovastatin is more efficiently absorbed. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Take simvastatin oral suspension (liquid) on an empty stomach. It is also used in the treatment of long-term complications such as heart disease or stroke. A proper diet and regular exercise should be maintained along with taking this medicine. Other Interactions . 2 of 10. but pulse dropped into the high 40s about 4 hours ago and is still hovering between 48 and 52. taking 120 mg of diltiazem every morning. Administration of a single 20 mg dose of simvastatin with 8 ounces of single-strength grapefruit juice increased the AUC of simvastatin and simvastatin acid by 1.9-fold and 1.3-fold, respectively. Consumer information for this interaction is not currently available. A proper diet and regular exercise should be maintained along with taking this medicine. Drug interactions are reported among people who take Simvastatin and Flecainide acetate. Select one or more newsletters to continue. Manufacturer advises adjust simvastatin dose. Severe Interactions. It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. Continue to follow the cholesterol-reducing diet recommended by your health care provider. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Epub 2012 Dec 5. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. Other Interactions . Although all statins may be affected by drug interactions, simvastatin is exceptionally sensitive for several reasons. Promptly consult your doctor or pharmacist. Author information: (1)Department of Pharmacy, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China. Both simvastatin and alectinib can increase the risk of hepatotoxicity. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Common side effects of Zocor include headache, nausea, vomiting, diarrhea, abdominal pain, muscle pain, abnormal liver tests, hypersensitivity reactions, memory loss, forgetfulness, amnesia, confusion, and memory impairment. https://www.webmd.com/drugs/2/drug-6105/simvastatin-oral/details Zetia, atorvastatin, Jardiance, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor, Crestor. Find everything you need to know about Zocor (Simvastatin), including what it is used for, warnings, reviews, side effects, and interactions. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Minimally clinically significant. Usually avoid combinations; use it only under special circumstances. Very Important. Should I avoid certain foods while taking Simvastatin? This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. A change in your diet, medicine, or dosage may be necessary. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Alectinib. It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. Common interactions include gastrooesophageal reflux disease among females and fatigue among males. J Clin Pharmacol 2004 Sep;44(9):1054-62. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There are 6 disease interactions with simvastatin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Simvastatin is usually taken in the evening or at bedtime. All rights reserved. Chlorzoxazone: (Moderate) One case report has noted a possible drug interaction between simvastatin and chlorzoxazone. For example, if a 20-mg dose is administered, only 1 mg reaches the systemic circulation. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Inform MD. It is also used in the treatment of long-term complications such as heart disease or stroke. Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans. Check out the following foods to eat (and avoid) for lower cholesterol numbers and a cleaner bill of health. also tal. HealthDay Reporter. Increased plasma concentrations resulting to increased risk of myopathy and rhabdomyolysis with grapefruit juice. Sign Up to Receive Our Free Coroanvirus Newsletter. Alectinib. Background: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). CAP (3, 8 or 25 mg/kg), ketoconazole, dexamethasone or 5% CMC-Na was … Zocor (simvastatin) is a statin drug that lowers total cholesterol, LDL cholesterol (bad cholesterol), and triglycerides, and boosts HDL cholesterol (good cholesterol). Amiodarone increases the risk of rhabdomyolysis when given with simvastatin. Simvastatin has the following interaction information: Alcohol. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. Action . Using alcohol or tobacco with certain medicines may also cause interactions to occur. Major Food Interaction. How Long Does Coronavirus Live On Surfaces? Drug interactions are reported among people who take Simvastatin and Coq10. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage.

simvastatin food interactions

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