Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Recommended dose: 40 mg PO … Cardiovascular risk reduction Patients with atherosclerotic CV disease or diabetes: 20-40 mg once daily in the evening. Key facts. When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Usual dosage range: 5-40 mg orally once/day. However, because renal impairment is a risk factor for statin-associated myopathy, dosages of the fixed-combination preparation exceeding ezetimibe 10 mg and simvastatin 20 mg daily should be used with caution and close monitoring in patients with moderate to severe renal impairment. In 4S involving 4,444 (age range 35-71 years, 19% women, 100% Caucasians) treated with 20-40 mg/day of simvastatin (n=2,221) or placebo (n=2,223) over a median of 5.4 years, adverse reactions reported in ≥2% of patients and at a rate greater than placebo are shown in Table 2. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. -Take on an empty stomach Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions. Adolescents (10-17 Years Of Age) With Heterozygous Familial Hypercholesterolemia -The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined. 10–15 % risk of major event in 10 years), max. -Obtain liver function tests prior to initiating therapy and as clinically indicated This information is generalized and not intended as specific medical advice. --LDL cholesterol remains 160 mg/dL or greater and there is a positive family history of premature cardiovascular disease (CVD), OR two or more other CVD risk factors are present, Mild to moderate renal dysfunction: No adjustment recommended Initial: 10-20 mg orally once/day in the evening. -Patients should be instructed to read the patient labeling. Both amlodipine and diltiazem are substrates and inhibitors of CYP3A4 2 3and therefore increase the plasma concentration (AUC0-24h) and maximum plasma concentration (Cmax) of simvastatin when they are co-administered. Maintenance dose: 5 to 40 mg orally once a day. Use: To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable. -High-risk patients may initiate at 40 mg orally once a day The following information includes only the average doses of this medicine. Uses: As an adjunct to diet to reduce total-C, LDL-C, and Apo B levels in adolescent boys and girls who are at least one year postmenarche (10 to 17 years) with heterozygous familial hypercholesterolemia (HeFH), if after an adequate trial of diet therapy the following findings are present: Take this medicine on the evening, on an empty stomach. 40 mg orally once a day Maximum dose: 40 mg orally once a day in the evening -Take orally once a day in the evening Zetia, atorvastatin, Jardiance, simvastatin, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor. -Hypersensitivity to active substance or any component of product Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Do not double doses. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. Maximum dose: 40 mg/day Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC): pravastatin or rosuvastatin); consider routine CK monitoring. Comments: For high risk patients who may develop heart disease, your doctor may start your dose at 40 mg per day. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you miss a dose of this medicine, take it as soon as possible. Is Repatha (evolocumab) effective without a statin. The dose of this medicine will be different for different patients. It's unusual to have any side effects. Drug Class Review on HMG-CoA Reductase Inhibitors (Statins). Simvastatin 80 mg is restricted to patients who have been taking simvastatin 80 mg chronically (for example, for 12 months … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Available for Android and iOS devices. -Concomitant administration of gemfibrozil, cyclosporine, or danazol 2.5 Adolescents (10 to 17 years of age) with Heterozygous Familial Hypercholesterolemia. Simvastatin seems to be a very safe medicine. -Coadministration of Strong CYP450 3A4 Inhibitors: Contraindicated; avoid consuming grapefruit juice during therapy -Patients should be advised to adhere to a diet and exercise program. Concomitant use of CYP3A4 inhibitors has the potential to increase exposure to simvastatin1. Drug information provided by: IBM Micromedex. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. Retrieved March 18, 2005, from Oregon Health and Sciences University, Drug Effectiveness Review Project Web This could cause unwanted effects on the liver. Portions of this document last updated: Nov. 01, 2020. Children 10 to 17 years of age—At first, 10 mg once a day in the evening. It lowers the level of cholesterol and triglycerides in the blood. We comply with the HONcode standard for trustworthy health information -, Heterozygous Familial Hypercholesterolemia. Maximum dose: 40 mg/day In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Maintenance dose: 5 to 40 mg orally once a day -Coadministration with Niacin 1 g/day or more: Not recommended for Chinese patients However, the dosage may range from 5 mg to 40 mg per day. Storage: Consult WARNINGS section for dosing related precautions. Typical starting dosage: Simvastatin is often started at 10–20 mg per day. simvastatin 20 mg tablet. -Patients should be instructed to report any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice. Patients at high CHD risk: Start 40 mg/day. -Coadministration with Verapamil, Diltiazem, or Dronedarone: Simvastatin dose should not exceed 10 mg/day Simvastatin Oral Suspension dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken 80 mg/day of simvastatin chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. This content does not have an English version. Applies to the following strengths: 80 mg; 5 mg; 10 mg; 20 mg; 40 mg; 20 mg/5 mL; 40 mg/5 mL. Shake the oral suspension well for at least 20 seconds before using it. However, the dose is usually not more than 40 mg per day. Initial dose: 10 to 20 mg orally once a day Ask your healthcare professional how you should dispose of any medicine you do not use. Initial dose: 10 to 20 mg orally once a day. May increase dose at intervals of at least 4 weeks. However, the dose is usually not more than 40 mg per day. People usually start with 10 or 20 mg daily, but those with high heart disease risk can start with 40 mg daily. Oral Suspension: -This drug has not been studied in patients with Fredrickson Types I and V dyslipidemias. Patients at high CHD risk: Start 40 mg/day. -Exposure to this drug is approximately doubled with concomitant use of lomitapide; therefore, if initiating lomitapide, reduce simvastatin by 50% or for patients who have tolerated 80 mg/day chronically, simvastatin should be decreased to 40 mg/day. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. Eating a diet of bland foods, while avoiding spicy or fried foods, may help diminish these side effects. Administration advice: Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Severe renal dysfunction: Initial dose: 5 mg orally once a day; monitor closely, Active liver disease or unexplained transaminase elevations: Contraindicated Usual dosage range: 5-40 mg PO qDay. Patient advice: -Lactation Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Adults—At first, 10 to 20 milligrams (mg) once a day in the evening. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. -High-risk patients may initiate at 40 mg orally once a day. CONTRAINDICATIONS: Homozygous Familial Hypercholesterolemia . Safety and efficacy have not been established in patients younger than 10 years, nor in pre-menarchal girls. Simvastatin side effects. -Patients should be instructed to discuss all medication use including herbal products and over the counter products with their healthcare professional; patients should be advised to avoid grapefruit juice during therapy. This site complies with the HONcode standard for trustworthy health information: verify here. -Use an accurate measuring dose; a household teaspoon is not an accurate measuring device Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Patients taking Simvastatin 20 mg may experience mild stomach pain, gas, bloating, stomach upset and heartburn, reports Drugs.com 1. -Oral Suspension: Store at room temperature (68F to 77F [20C to 25C]); Protect from heat; do not freeze or refrigerate; Use within 30 days after opening Do not drink large amounts of alcohol with simvastatin. All rights reserved. Carefully follow your doctor's orders about any special diet. Restricted Use (due to myopathy risk): 80 mg/day should only be used in patients who have been taking this drug chronically (e.g. Children under 10 years: Safety and efficacy not established -Periodic creatine kinase determinations may be considered to monitor for myopathy, however, there is no assurance that such monitoring will prevent myopathy Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Dosage forms: TAB: 5 mg, 10 mg, 20 mg, 40 mg, 80 mg Special Note [restricted 80 mg dose] Info: max simvastatin dose 40 mg/day; as of 6/8/2011, any pt previously on 80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. Your doctor may increase your dose as needed. 10 mg 40 mg 20 mg 20 mg 20 mg 10 mg 80 mg 40 or 80 mg 40 mg 40 mg 20 mg 80 mg 80 mg 5 or 10 mg 80 mg 40 mg 80 mg 20 mg 40 mg *Helfand, M., Carson, S., Kelley, C. (2004). See our safe care and visitor guidelines, plus trusted coronavirus information. Simvastatin exposure is approximately doubled with concomitant use of lomitapide; therefore, the dose of ZOCOR should be reduced by 50% if initiating lomitapide. Select one or more newsletters to continue. Approximately 78 % and also 11 % of the administered radioactivity were recovered in the feces and also pee, specifically, over a 10-day collection period. ... simvastatin 20 mg tablet. -Substantial alcohol ingestion and/or past history of liver disease: Use with caution Copyright © 2020 IBM Watson Health. Restricted Use (due to myopathy risk): 80 mg/day should only be used in patients who have been taking this drug chronically (e.g. The dose is one simvastatin 5mg, 10mg, 20mg, 40mg or 80mg Tablet by mouth once a day. ZOCOR dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken ZOCOR 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. Drug therapy can be initiated simultaneously with diet and exercise. 2.5 Adolescents (10-17 years of age) with Heterozygous Familial Hypercholesterolemia. Last updated on Oct 6, 2020. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels -The minimum goal of treatment in pediatric and adolescent patients is to achieve a mean LDL-C less than 130 mg/dL. Find Lowest Prices. Follow your doctor's orders or the directions on the label. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients. If your dose is different, do not change it unless your doctor tells you to do so. ZOCOR dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken ZOCOR 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. -Patients with severe renal impairment should be closely monitored simvastatin. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. Max: 80 mg daily. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Patients should be placed on a cholesterol-lowering diet and other lifestyle modification prior and during drug therapy. -Lipids should be checked 4 weeks after initiating therapy; patients unable to achieve LDL-C goal with 40 mg/day should be placed on alternative LDL-C lowering therapy. Uses: As one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia, specifically: daily dose 10 mg and pack size of 28 tablets; treatment should form part of a programme to reduce risk of coronary heart disease. Restricted Use (due to myopathy risk): 80 mg/day should only be used in patients who have been taking this drug chronically (e.g. For high risk patients who may develop heart disease, your doctor may start your dose at 40 mg per day. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. --This drug is indicated in patients at high risk of CHD events: to reduce the risk of total mortality by reducing CHD deaths; to reduce the risk of nonfatal myocardial infarction and stroke; and to reduce the need for coronary and non-coronary revascularization procedures. -Simvastatin 80 mg dose should only be used in patients who have taken this dose chronically (e.g., for 12 months or more) without evidence of muscle toxicity Simvastatin is metabolised through the CYP3A4 pathway. You should take this drug once a day in the evening. If you are taking diltiazem (Cardizem®), dronedarone (Multaq®), or verapamil (Calan®, Isoptin®, Verelan®) together with simvastatin, your simvastatin dose should not be higher than 10 milligrams (mg) per day, unless otherwise directed by your doctor. Comments: -Shake well for at least 20 seconds before measuring dose Adolescents (10 to 17 years of age) With Heterozygous Familial Hypercholesterolemia Monitor: Initial dose: Ezetimibe 10 mg-simvastatin 10 mg OR ezetimibe 10 mg-simvastatin 20 mg orally once a day in the evening-Patients requiring a larger reduction in LDL-C (e.g., greater than 55%): May initiate with ezetimibe 10 mg-simvastatin 40 mg orally once a day in the evening Initial: 10-20 mg PO qDay in the evening. The amount of medicine that you take depends on the strength of the medicine. The usual dose of simvastatin is 20 to 40 mg/day given as a single dose in the evening in patients at high risk of coronary heart disease (CHD, with or without hyperlipidaemia). Precautions. for 12 months or more) without evidence of muscle toxicity Mayo Clinic does not endorse companies or products. Read More. -Normal Function SLCO1B1 Phenotype: Follow prescribed dosing guidelines and adjust doses based on disease-specific guidelines SIMVASTATIN (SIM va stat in) is known as a HMG-CoA reductase inhibitor or 'statin'. -Women of childbearing potential should be advised to use an effective method of birth control. -Pregnancy for 12 months or more) without evidence of muscle toxicity Maintenance dose: 10 to 40 mg orally once a day in the evening The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. --LDL cholesterol remains 190 mg/dL or greater, OR For children (10-17 years old), the recommended usual starting dose is 10mg a day in the Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). -Doses should be individualized according to the goal of therapy; dose adjustments should be made at intervals of 4 weeks or more. -Concomitant administration of strong CYP450 3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat containing products) -Chinese patients may be a higher risk of myopathy and should be closely monitored dose to 80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 40 mg/day Drinking large amounts of grapefruit juice (more than 1 quart each day) while taking this medicine may increase your risk of muscle injury and could result in kidney problems. Studies have found that after 10 days of amlodipine (10 mg), the AUC0-24h of simvastatin and simvastatic acid following a singl… In the Multicenter Anti-Atheroma Study (MAAS), 381 patients were treated with diet and either simvastatin 20 mg/day PO or placebo for a period of four years. Adjustments of dosage, if … Zocor (simvastatin) is a lipid-lowering broker that is derived synthetically from a fermentation devices of Aspergillus terreus. For oral dosage forms (suspension or tablets): Adults—At first, 10 to 20 milligrams (mg) once a day in the evening. -If a patient on simvastatin 80 mg/day needs to initiate an interacting drug (one that will increase simvastatin concentrations); simvastatin should be switched to an alternative statin with less potential for drug-drug interaction. Keep from freezing. Advertising revenue supports our not-for-profit mission. Adult Dosing . Your doctor may adjust your dose as needed. Children 10 to 17 years of age—At first, 10 mg once a day in the evening. Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx. Initial dose: 10 mg orally once a day in the evening General: Simvastatin (Less Than or Equal To 20 mg)/Amlodipine Interactions. Maximum dose: 40 mg/day. for 12 months or more) without evidence of muscle toxicity. -High risk patients include those at high risk for coronary heart disease (CHD) events due to existing CHD, diabetes, peripheral vessel disease, history of stroke or other cerebrovascular disease; in these patients, therapy can be initiated at a higher dose simultaneously with diet (restricted in saturated fat and cholesterol). --This drug is indicated in patients with hyperlipidemia: to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), triglycerides (TG), and increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb); to reduce elevated TG in patients with hypertriglyceridemia (Fredrickson type IV hyperlipidemia); and to reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type III hyperlipidemia). Tell your doctor if you regularly drink grapefruit juice. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Atorvastatin: 10 mg, 20 mg, 40 mg, and 80 mg The costs of generic simvastatin and atorvastatin are both fairly low, with generic simvastatin being … However, the dose is usually not more than 40 mg per day. -Patients should understand the risk of myopathy and should be instructed to report unexplained muscle pain promptly, especially if accompanied by malaise or fever. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. color tan shape round imprint 7154, TV. This content does not have an Arabic version. List Simvastatin side effects by likelihood and severity. The 80-mg dose lowers the LDL cholesterol by an additional 6% over simvastatin 40 mg. Interrupt therapy if serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice develop; investigate cause, if an alternative etiology is not found, do not restart, Restricted Use of Simvastatin 80 mg/day: -Coadministration with Amiodarone, Amlodipine, or Ranolazine: Simvastatin dose should not exceed 20 mg/day Take this medicine only as directed by your doctor. The usual dosage range is 20 to 40 mg PO once daily. This drug may also reduce the risk of heart attack, stroke, or other health problems in patients with risk factors for heart or blood vessel disease. 10 years or older: All rights reserved. Children younger than 10 years of age—Use and dose must be determined by your doctor. Simvastatin dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken simvastatin 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. Comments: (See Dosage and Administration: Special Populations.) Do not keep outdated medicine or medicine no longer needed. -Coadministration of Lomitapide: Simvastatin dose should not exceed 20 mg/day in patients with HoFH (for patients who have tolerated simvastatin 80 mg/day chronically, a dose of simvastatin 40 mg may be used) ZOCOR dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken ZOCOR 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. Keep … Taking this medication with food or milk may help alleviate gastrointestinal discomfort. Use a marked measuring spoon, oral syringe, or medicine cup to measure the right dose. Your doctor may adjust your dose as needed. Medically reviewed by Drugs.com. In particular, caution should be used when treating Chinese patients with simvastatin doses exceeding 20 mg/day coadministered with lipid-modifying doses of niacin-containing products. Are Statin Side Effects 'All in Your Head'? -Intermediate and Low Function SLCO1B1 Phenotype: Initiate therapy with a lower dose or consider an alternative statin (e.g.

simvastatin dosage 20 mg

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simvastatin dosage 20 mg 2020